Acetamidozole 2-Acetamido-5-nitrothiazole
Structural formula
| Business number | 03T1 |
|---|---|
| Molecular formula | C5H5N3O3S |
| Molecular weight | 187.18 |
| label |
2-acetamido-5-nitrothiazole, 2-acetamido-5-nitrothiazole, 5-Nitro-2-acetilaminotiazolo, aromatic compounds |
Numbering system
CAS number:140-40-9
MDL number:MFCD00022438
EINECS number:205-414-7
RTECS number:XJ1570000
BRN number:None
PubChem ID:None
Physical property data
1. Physical property data
1.Characteristics: white crystalline powder, slightly odorous, almost tasteless
2.Melting point (℃): 264～266℃(decomposes ).
3.Solubility: in sodium hydroxide(potassium)lye and ammonia Moderately soluble, soluble in ethanol, slightly soluble in chloroform, slightly soluble in ether, almost insoluble in water
Toxicological data
2. Toxicological data:
1, Acute toxicity: Rat abdominal cavity LD50: >200 mg/kg;
Rat orally LD50 ：>400 mg/kg;
Rat subcutaneous LD: >3200 mg/kg;
Orally administered to mice LD50 ：200 mg/kg;
Mouse abdominal cavity LD50: >300 mg/kg;
Mouse subcutaneous LD: >3200 mg/kg.
Ecological data
3. Ecological data:
1, other harmful effects: This substance may be harmful to the environment, special attention should be paid to water bodies.
Molecular structure data
5. Molecular property data: 1. Molar refractive index:43.54 2. Molar volume (m3/ mol):117.0 3. Isotonic specific volume (90.2K): 343.8 4. Surface tension (dyne/cm): 74.4 5. Polarizability（10-24cm3):17.26
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond acceptors: 5
4. Number of rotatable chemical bonds: 1
5. Number of tautomers: 5
6. Topological molecule polar surface area 116
7. Number of heavy atoms: 12
8. Surface charge: 0
9. Complexity: 205
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
Stable under normal temperature and pressure.
Storage method
Stored sealed in a dry and cool place.
Synthesis method
By2-Aminothiazole is used as raw material.
Purpose
3. Isotonic specific volume (90.2K):343.8
4. Surface tension (dyne/cm): 74.4
5. Polarizability（10-24cm3):17.26
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond acceptors: 5
4. Number of rotatable chemical bonds: 1
5. Number of tautomers: 5
6. Topological molecule polar surface area 116
7. Number of heavy atoms: 12
8. Surface charge: 0
9. Complexity: 205
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
Stable under normal temperature and pressure.
Storage method
Stored sealed in a dry and cool place.
Synthesis method
By2-Aminothiazole is used as raw material.
Purpose
It is suitable for oral treatment of trichomoniasis, and can also be used for the treatment of amoebic and intestinal bacterial infections.
tyle=”FONT-SIZE: 10pt; COLOR: #333333; FONT-FAMILY: 宋体; mso-ascii-font-family: ‘Times New Roman’; mso-hansi-font-family: ‘Times New Roman'”>Applicable It is used for the oral treatment of trichomoniasis and can also be used to treat amoebic and intestinal bacterial infections.
