chlorpropamide
Structural formula
| Business number | 027D |
|---|---|
| Molecular formula | C10H13ClN2O3S |
| Molecular weight | 276.74 |
| label |
1-(4-chlorophenylsulfonyl)-3-propylurea, p-chlorophenylsulfonamide, 1-(p-Chlorobenzenesulfonyl)-3-propylurea |
Numbering system
CAS number:94-20-2
MDL number:MFCD00079004
EINECS number:202-314-5
RTECS number:YS6650000
BRN number:None
PubChem number:24277701
Physical property data
1. Properties: white crystalline powder, odorless and tasteless.
2. Density (g/mL, 25/4℃): Undetermined
3. Relative vapor density (g/mL, air=1): Undetermined
4. Melting point (ºC): 127-129
5. Boiling point (ºC, normal pressure): Undetermined
6. Boiling point (ºC, 5.2kPa): Undetermined
7. Refractive index: Undetermined
8. Flash point (ºC): Undetermined
9. Specific rotation (º): Undetermined Determined
10. Autoignition point or ignition temperature (ºC): Not determined
11. Vapor pressure (kPa, 25ºC): Not determined
12. Saturated vapor pressure (kPa, 60ºC): Undetermined
13. Heat of combustion (KJ/mol): Undetermined
14. Critical temperature (ºC): Undetermined
15. Critical pressure (KPa): Undetermined
16. Log value of oil-water (octanol/water) partition coefficient: Undetermined
17. Explosion upper limit ( %, V/V): Undetermined
18. Lower explosion limit (%, V/V): Undetermined
19. Solubility: Easily soluble in chloroform and acetone, slightly Soluble in ether and benzene, the solubility in water with pH 6 is 2.2mg/ml, and insoluble in water with pH 7.3.
Toxicological data
None yet
Ecological data
None yet
Molecular structure data
1. Molar refractive index: 66.33
2. Molar volume (cm3/mol): 207.4
3. Isotonic specific volume (90.2K ): 542.3
4. Surface tension (dyne/cm): 46.7
5. Polarizability (10-24cm3): 26.29
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond acceptors: 3
4. Number of rotatable chemical bonds: 4
5. Number of tautomers: 3
6. Topological molecule polar surface area 83.6
7. Number of heavy atoms: 17
8. Surface charge: 0
9. Complexity: 345
10. Number of isotope atoms: 0
11. Determining the atomic configurationNumber of stereocenters: 0
12. Uncertain number of stereocenters of atoms: 0
13. Determined number of stereocenters of chemical bonds: 0
14. Uncertain Number of stereocenters of chemical bonds: 0
15. Number of covalent bond units: 1
Properties and stability
None yet
Storage method
This product should be kept sealed.
Synthesis method
P-chlorobenzenesulfonylpropionamide sodium salt is obtained by reacting p-chlorobenzenesulfonamide and butanamide. Then acidify and refine with hydrochloric acid to obtain the finished product. Another method is to use p-chlorobenzenesulfonamide, propyl isocyanate, and triethylamine as raw materials.
Purpose
UV absorber. Mainly used in sunscreen and tanning cosmetics, it is chemically stable to light and air, safe for the skin, and has the ability to form a film on the skin. Can effectively absorb U. V． B area 280-320μm medium wave light area) ultraviolet light. The added amount is usually about 4%.
Sulfonylureas are oral hypoglycemic drugs. It has a strong and long-lasting effect, mainly selectively acting on pancreatic islet-β-cells, promoting the secretion of pancreatic islets and lowering blood sugar. Used for diabetes. Chlorpropamide has relatively serious side effects, so the use of this drug has been decreasing year by year.
