Sulfadiazine Sulfadiazine
Structural formula
| Business number | 01FB |
|---|---|
| Molecular formula | C10H10N4O2S |
| Molecular weight | 250.28 |
| label |
sulfadiazine, 2-p-Aminobenzenesulfonamidepyrimidine, Diyajing, Sulfapyridazine, zinc sulfadiazine, N-2-pyrimidinyl-4-aminobenzenesulfonamide, great tranquility, xiafadiajing |
Numbering system
CAS number:68-35-9
MDL number:MFCD00006065
EINECS number:200-685-8
RTECS number:WP1925000
BRN number:6733588
PubChem number:24899802
Physical property data
1. Character: white or off-white crystal or powder, odorless, tasteless, gradually darkens when exposed to light
2. Density (g/mL, 25/4℃): Uncertain
3. Relative vapor density (g/mL, air=1): Uncertain
4. Melting point (ºC): 253 (dec.)(lit.)
5. Boiling point (ºC, normal pressure): Uncertain
6. Boiling point (ºC, 5.2kPa): Uncertain
7. Refractive index: Uncertain
8. Flash point (ºC): Uncertain
9. Specific rotation (º): Uncertain
10. Autoignition point or ignition temperature (ºC): Uncertain
11. Vapor pressure (kPa, 25ºC): Uncertain
12. Saturated vapor pressure (kPa, 60ºC): Uncertain
13. Heat of combustion (KJ/mol): Uncertain
14. Critical temperature (ºC): Uncertain
15. Critical pressure (KPa): Uncertain
16. Log value of oil-water (octanol/water) partition coefficient: Uncertain
17. Explosion upper limit (%, V/V): Uncertain
18. Explosion lower limit (%, V/V): Uncertain
19. Solubility: Almost insoluble in water. At 37°C, the solubility in water with pH=5.6 is 13mg/100ml, and the solubility in water with pH=7.5 is 13mg/100ml. 200mg/100ml. Slightly soluble in ethanol or acetone, easily soluble in dilute hydrochloric acid, sodium hydroxide solution or ammonia solution
Toxicological data
None
Ecological data
None
Molecular structure data
1. Molar refractive index: 63.14
2. Molar volume (cm3/mol): 167.2
3. Isotonic specific volume (90.2K ): 504.4
4. Surface tension (dyne/cm): 82.6
5. Polarizability (10-24cm3): 25.03
Computing chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond acceptors: 6
4. Number of rotatable chemical bonds: 3
5. Number of tautomers: 2
6. Topological molecule polar surface area 106
7. Number of heavy atoms: 17
8. Surface charge: 0
9. Complexity: 327
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
Keep in a sealed container away from light.
Synthesis method
It can be prepared by synthesizing 2-aminopyrimidine from furochloric acid and nitroguanidine, and then condensing and hydrolyzing it with p-acetylbenzenesulfonyl chloride in pyridine.
Purpose
This product is a medium-effective sulfonamide for the treatment of systemic infections. It has a broad antibacterial spectrum and has inhibitory effects on most Gram-positive and negative bacteria. It is effective against Neisseria meningitidis, Streptococcus pneumoniae, Neisseria gonorrhoeae, and hemolytic chain bacteria. The inhibitory effect of cocci is strong and can penetrate into the cerebrospinal fluid through the blood-brain barrier.
It is mainly used clinically for meningococcal meningitis and is the first choice drug for treating meningococcal meningitis. It can also treat other infections caused by the above-mentioned sensitive bacteria. It is also often made into a water-soluble sodium salt and used as an injection.
