Methotrexate Methotrexate
Structural formula
| Business number | 01A4 |
|---|---|
| Molecular formula | C20H22N8O5 |
| Molecular weight | 454.45 |
| label |
(+)-Amethopterin, 4-Amino-10-methylfolic acid, 4-Amino-N10-methylpteroyl-L-glutamic acid, Antifolan, Methylaminopterin, MTX |
Numbering system
CAS number:59-05-2
MDL number:MFCD00064370
EINECS number:200-413-8
RTECS number:MA1225000
BRN number:70669
PubChem number:24897373
Physical property data
1. Characteristics: yellow crystal. Odorless.
2. Density (g/mL,25/4℃): Undetermined
3. Relative vapor density (g/mL,air=1): Undetermined
4. Melting point (ºC): Undetermined
5. Boiling point (ºC,Normal pressure): Undetermined
6. Boiling point (ºC,5.2kPa): Undetermined
7. Refractive index: Undetermined
8. Flashpoint (ºC): Undetermined
9. Specific optical rotation (º): SPAN>Undetermined
10. Autoignition point or ignition temperature (ºC): Undetermined
11. Vapor pressure (kPa,25ºC9. Complexity: 704
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 1
12. The number of uncertain atomic stereocenters: 0
13. Determine the number of stereocenters of chemical bonds: 0
14. Uncertain number of chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None yet
Storage method
Sealing4Store dry at ℃.
Synthesis method
By2,4,5,6- It is obtained by cyclizing tetraaminopyrimidine with dibromopropionaldehyde and then condensing it with p-methylaminobenzoylglutamic acid.
Purpose
Folic acid antagonizes Liu. A potent inhibitor of dihydrofolate reductase. Immunosuppressants. Tissue culture reagents.
This product is a good anti-tumor drug, used for acute lymphoblastic leukemia, lymphoma, malignant mole, choriocarcinoma, and squamous epithelium cancer, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc. Oral methotrexate12hAfter the original drug90%Excreted in urine, the main metabolite is7-Hydroxymethotrexate. Intravenous injection in ratsLD50 for14mg/kg.
font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt”>,4,5,6-It is obtained by cyclizing tetraaminopyrimidine with dibromopropionaldehyde and then condensing it with p-methylaminobenzoylglutamic acid.
Purpose
Folic acid antagonizes Liu. A potent inhibitor of dihydrofolate reductase. Immunosuppressants. Tissue culture reagents.
This product is a good anti-tumor drug, used for acute lymphoblastic leukemia, lymphoma, malignant mole, choriocarcinoma, and squamous epithelium cancer, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc. Oral methotrexate12hAfter the original drug90%Excreted in urine, the main metabolite is7-Hydroxymethotrexate. Intravenous injection in ratsLD50 for14mg/kg.
