Chloropromazine Chloropromazine
Structural formula
| Business number | 013V |
|---|---|
| Molecular formula | C17H19ClN2S |
| Molecular weight | 318.87 |
| label |
chlorpromazine, 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine |
Numbering system
CAS number:50-53-3
MDL number:None
EINECS number:200-045-8
RTECS number:None
BRN number:None
PubChem ID:None
Physical property data
1. Character:The hydrochloride is commonly used. White or milky white crystalline powder. Slightly smelly. Extremely bitter
2. Density (g/mL ,25/4℃): Undetermined
3. Relative vapor density (g/mL,air=1): Undetermined
4. Melting point (ºC):194~198℃
5. Boiling point (ºC,Normal pressure): Undetermined
6. Boiling point (ºC, 5.2 kPa): Undetermined
7. Refractive index:Undetermined
8. Flash point (ºC): Undetermined
9. Specific optical rotation (º ): Undetermined
10. Autoignition point or ignition temperature (ºC): Undetermined
11. Vapor pressure (kPa, 25 ºC): Undetermined
17. Explosion upper limit (%,V/V): Undetermined
18. Lower explosion limit (%, V/V): Undetermined
19. Solubility:Easily soluble in water, ethanol and chloroform, insoluble in ether and benzene
Toxicological data
None
Ecological data
None
Molecular structure data
None
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 0
3. Number of hydrogen bond acceptors: 3
4. Number of rotatable chemical bonds: 4
5. Number of tautomers: none
6. Topological molecule polar surface area 31.8
7. Number of heavy atoms: 21
8. Surface charge: 0
9. Complexity: 339
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
This product is sealed and stored in a dry place away from light.
Synthesis method
By2-Chlorophenothiazine[92-39 -7]Condensation and salt formation. 1.Condensation is added to the reaction pot2-chlorophenothiazine and toluene, then add sodium hydroxide , stir and heat to reflux, remove moisture, and set at 110℃drop1-chlorine-3-Toluene solution of dimethylaminopropane, depressurize the reactant to recover toluene to obtain chlorpromazine,C17H19CIN2S，[50-53-3]. 2. Salt Stir and heat chlorpromazine and isopropyl alcohol until40℃, add dry hydrogen chloride topH4-5, to obtain chlorpromazine hydrochloride as a salt.
Purpose
Representative drugs among phenothiazines. It has a stabilizing effect on the central nervous system in small doses, and has an antipsychotic effect when used continuously in large doses. This product inhibits the subthalamic thermoregulatory center, causing the body temperature to rise and fall with the ambient temperature. It can be used with other drugs to reduce the body temperature to below normal body temperature, and improves metabolism. Reducing is called artificial hibernation. Mainly used for antipsychotics, enhancing the effects of hypnotics, anesthetics, analgesics and anticonvulsants. It can also be used to relieve vomiting and intractable hiccups and induce artificial hibernation.
New Roman”>[92-39-7]Condensation and salt formation.1.Condensation in the reaction pot2-Chlorophenothiazine and toluene, then add sodium hydroxide, stir and heat to reflux, remove moisture, and in110℃drop1-Chlorine-3-Dimethylamine A toluene solution of propane is used, and the reactant is decompressed to recover toluene to obtain chlorpromazine,C17H19CIN2S,[50-53- 3]. 2. Salt Stir and heat chlorpromazine and isopropyl alcohol until40℃, add dry hydrogen chloride topH4-5, to obtain chlorpromazine hydrochloride as a salt.
Purpose
Representative drugs among phenothiazines. It has a stabilizing effect on the central nervous system in small doses, and has an antipsychotic effect when used continuously in large doses. This product inhibits the subthalamic thermoregulatory center, causing the body temperature to rise and fall with the ambient temperature. It can be used with other drugs to reduce the body temperature to below normal body temperature, and improves metabolism. Reducing is called artificial hibernation. Mainly used for antipsychotics, enhancing the effects of hypnotics, anesthetics, analgesics and anticonvulsants. It can also be used to relieve vomiting and intractable hiccups and induce artificial hibernation.
