Chloropromazine Hydrochlorode Chloropromazine Hydrochlorode
Structural formula
| Business number | 01FJ |
|---|---|
| Molecular formula | C17H20Cl2N2S |
| Molecular weight | 355.34 |
| label |
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, hibernation spirit, Colagent, Chlorpromazine, aminazine, chlorpromazine, Chlorpromazine hydrochloride, Hibernating phosphorus, C17H19ClN2S·HCl |
Numbering system
CAS number:69-09-0
MDL number:MFCD00012654
EINECS number:200-701-3
RTECS number:200-701-3
BRN number:3779989
PubChem number:24277891
Physical property data
1. Character:White or milky white crystalline powder, hygroscopic, slightly odorous, extremely bitter in taste, easily oxidized in air or Gradates to reddish brown in sunlight
2. Density (g/mL,25/4℃): Unsure
3. Relative vapor density (g/mL,AIR=1): Unsure
4. Melting point (ºC):179-180℃（ 194-196℃ ).
5. Boiling point (ºC,Normal pressure): Uncertain
6. Boiling point (ºC, 5.2kPa): Unsure
7. Refractive index:Not sure
8. Flash point (ºC): Unsure
9. Specific optical rotation (º): Unsure
10. Autoignition point or ignition temperature (ºC): No�Quantity: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine chemical bonds Number of stereocenters: 0
14. Number of stereocenters of uncertain chemical bonds: 0
15. Number of covalent bond units: 2
Properties and stability
None
Storage method
Keep it sealed and protected from light.
Synthesis method
By2-Chlorophenothiazine[92-39-7]Condensation and salt formation. 1.Condensation in reaction Add 2- Chlorophenothiazine and toluene, then add sodium hydroxide, stir and heat to reflux, remove moisture, and in 110℃ dripping1-Chlorine-3-Toluene solution of dimethylaminopropane, the reactant is decompressed to recover toluene to obtain chlorpromazine,C17H19CIN2S,[50-53-3]. 2.Salt Stir and heat chlorpromazine and isopropyl alcohol until 40℃, access dry hydrogen chloride to pH 4-5, to obtain chlorpromazine hydrochloride as a salt.
Purpose
has central stabilizing, antiemetic, anticonvulsant, anti- Adrenaline and other effects. Used to treat schizophrenia and mania. Anxiety disorders, mental disorders, nausea, vomiting, etc. It can also be used for artificial hibernation and low-temperature anesthesia.
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Purpose
has central stabilizing, antiemetic, anticonvulsant, anti- Adrenaline and other effects. Used to treat schizophrenia and mania. Anxiety disorders, mental disorders, nausea, vomiting, etc. It can also be used for artificial hibernation and low-temperature anesthesia.
