Haloperidol Haloperidol
Structural formula
| Business number | 015P |
|---|---|
| Molecular formula | C21H23ClFNO2 |
| Molecular weight | 375.86 |
| label |
haloperidol, halopyridol, 1-(4-Fluorophenyl)-4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-butanone, iohexol, haloperidol, 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone, 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobut |
Numbering system
CAS number:52-86-8
MDL number:MFCD00051423
EINECS number:200-155-6
RTECS number:EU1575000
BRN number:None
PubChem number:24277917
Physical property data
1. Characteristics: White or off-white crystalline powder. Odorless and tasteless.
2. Density ( g/mL,25/4℃）： Undetermined SPAN>
3. Relative steam Density (g/mL,AIR=1): Undetermined
4. Melting point ( ºC):148-149.4
5. Boiling point ( ºC,Normal pressure): Undetermined
6. Boiling point ( ºC, 13.33kpa):
7. Refractive Index ： Undetermined
8. Flashpoint (ºC): Undetermined
9. Specific optical activity Degree (º,）： Undetermined
10. Spontaneous ignition point or ignition temperature (ºC): Undetermined
11. Vapor Pressure (kPa,25ºC): Undetermined
Isotonic specific volume(90.2K)： 797.8
4. Surface Tension(dyne/cm)：47.9
5. Polarizability(10-24cm3)：40.04
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond acceptors: 4
4. Number of rotatable chemical bonds: 6
5. Number of tautomers: 2
6. Topological molecule polar surface area 40.5
7. Number of heavy atoms: 26
8. Surface charge: 0
9. Complexity: 451
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
Should be sealed and stored away from light.
Synthesis method
By4-p-chlorobenzene-4-hydroxyl piper andγ–Chloro-p-fluorophenbutanone condensation And get. IntermediateγChlorofluorobenzene is composed of fluorobenzene,γ–butyrolactone and sulfoxide chloride as raw materials.
Purpose
Antipsychotic drugs, formerly known as strong tranquilizers, are mainly used to control schizophrenia and other patients with hallucinations, delusions, Excitement, impulsiveness and other related diseases. Haloperidol is mainly used to combat mania and hallucinations in acute and chronic schizophrenia. It is effective in controlling excitement and agitation, but it is ineffective in treating depression and apathy in schizophrenia.
LY: Times New Roman; LETTER-SPACING: 0.4pt; mso-hansi-font-family: 宋体”>-Made from butyrolactone and sulfoxide chloride as raw materials.
Purpose
Antipsychotic drugs, formerly known as strong tranquilizers, are mainly used to control schizophrenia and other patients with hallucinations, delusions, Excitement, impulsiveness and other related diseases. Haloperidol is mainly used to combat mania and hallucinations in acute and chronic schizophrenia. It is effective in controlling excitement and agitation, but it is ineffective in treating depression and apathy in schizophrenia.
