Methylmagnesium bromide Methylmagnesium bromide
Structural formula
| Business number | 01J3 |
|---|---|
| Molecular formula | CH3MgBr |
| Molecular weight | 119.24 |
| label |
Grignard reagent, format reagent |
Numbering system
CAS number:75-16-1
MDL number:MFCD00000041
EINECS number:200-844-1
RTECS number:OM3700000
BRN number:3535220
PubChem number:24858252
Physical property data
1. Properties: solid
2. Density (g/mL, 20℃): 1.035
3. Relative vapor density (g/mL, air=1): Undetermined
4. Melting point (ºC): Undetermined
5. Boiling point (ºC, normal pressure): Undetermined
6. Boiling point (ºC, 5.2kPa): Not determined
7. Refractive index: Not determined
8. Flash point (ºF): 77
9. Specific rotation (º ): Undetermined
10. Autoignition point or ignition temperature (ºC): 160
11. Vapor pressure (kPa, 25ºC): Undetermined
12. Saturated vapor pressure (kPa, 60ºC) not determined:
13. Heat of combustion (KJ/mol): not determined
14. Critical temperature (ºC): not determined
15. Critical pressure (KPa): Undetermined
16. Log value of oil-water (octanol/water) partition coefficient: Undetermined
17. Explosion Upper limit (%, V/V): Undetermined
18. Lower explosion limit (%, V/V): Undetermined
19. Solubility: Reacts strongly with water, producing Combustible gas
Toxicological data
None yet
Ecological data
None yet
Molecular structure data
None yet
Calculate chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 0
3. Number of hydrogen bond acceptors: 2
4. Number of rotatable chemical bonds: 0
5. Number of tautomers: none
6. Topological molecule polar surface area 0
7. Number of heavy atoms: 3
8. Surface charge: 0
9. Complexity: 4.8
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 3
Properties and stability
Reacts with water, oxides, acids, alkalis, and alcohols.
Sensitive to water, light and air.
Storage method
Store in a cool, dry, well-ventilated non-combustible warehouse. Keep away from fire and heat sources. The warehouse temperature should not exceed 28℃.The packaging must be sealed and must not come into contact with air. Keep away from light. Not suitable for large quantities or long-term storage. It should be stored separately from acids, flammables, combustibles, oxidants, oxygen, compressed air, etc. The lighting, ventilation and other facilities in the storage room should be explosion-proof, and the switches should be located outside the warehouse. Equipped with the appropriate variety and quantity of fire equipment. Fire and explosion prevention technical measures must be taken during tank storage. It is prohibited to use mechanical equipment and tools that are prone to sparks. When handling, load and unload with care to prevent damage to packaging and containers. Smoking, drinking, and eating are not allowed at the operation site.
Synthesis method
Use carbide tools to cut single crystal magnesium flakes with a purity of 99.999%, wash them several times with ether treated with lithium aluminum tetrahydride, and add a dry ice-acetone condenser tube. And in the reaction bottle directly connected to the ether distillation device. The device is repeatedly baked with gas lamps and filled with high-purity nitrogen several times. Add dry ice to the condenser tube, evaporate 50 mL of ether directly into the flask, and then introduce a small amount of ethyl bromide from the side tube installed near the bottom of the condenser tube. Bubbles are released and heat is released, proving that the reaction has begun. Thereafter, continue to pass in methyl bromide and steam into ether. Keep methyl bromide and ether at reflux without heating until the magnesium metal reacts completely. During this period, it is appropriate to keep the ether solution at about 300 mL. Remove the flask in the nitrogen flow and put it in the operation box with a stopper, filter it into the flask with a glass sand funnel, and cover it with a tetrafluoroethylene piston. A colorless and transparent methylmagnesium bromide solution was obtained. The ratio of the analytical values of C:Mg:Br is 1.00:1.03:0.99.
Purpose
for organic synthesis
