Scopolamine Hydrobromide Scopolamine Hydrobromide
Structural formula
| Business number | 037B |
|---|---|
| Molecular formula | C17H22BrNO4 |
| Molecular weight | 384.26 |
| label |
Scopolamine hydrobromide, Hyoscyamine hydrobromide, Scopolamine bromide, Hyoscine hydrobromide, Hyoscine hydrochloride, Anesthetic, aromatic compounds |
Numbering system
CAS number:114-49-8
MDL number:MFCD00012647
EINECS number:204-050-6
RTECS number:YM4550000
BRN number:None
PubChem ID:None
Physical property data
1. Characteristics: White orthorhombic crystals , Odorless and bitter.
2. Density (g/mL, 25℃): Undetermined
3. Relative vapor density (g/mL,Air =1): Undetermined
4. Melting point (ºC):195
5. Boiling point (ºC,normal pressure): Undetermined
6. Boiling point (ºC,KPa)：Undetermined
7. Refractive Index （n20/D）：Undetermined
8. Flashpoint (ºC): Undetermined
9. Specific rotation (ºC): Undetermined
10. Autoignition point or ignition temperature (ºC): Undetermined
11. Vapor pressure (mmHg,38ºC): Undetermined
12. Saturated vapor pressure (kPa, ºC): Undetermined
13. Heat of combustion (KJ/mol): Undetermined
14. Critical temperature (ºC): Undetermined
15. Critical pressure (KPa): Undetermined
Complexity:418
10. Number of isotope atoms:0
11. Determine the number of atomic stereocenters:5
12. Uncertain number of atomic stereocenters:0
13. Determine the number of stereocenters of chemical bonds:0
14. Uncertain number of chemical bond stereocenters:0
15. Number of covalent bond units: 2
Properties and stability
None yet
Storage method
Store in a sealed, dry, and away from light.
Synthesis method
Scopolamine is extracted from Amaranthus japonica as raw material. China’s traditional Chinese medicine anesthetic preparation, Yangjinhua, originated from the Mafei Powder of Huatuo, a famous doctor in the 2nd century AD. Its active ingredient is scopolamine. Use the goldenrod powder with 50℃Ethanol was percolated until the exudate was almost free of alkaloids. The leachate is distilled under reduced pressure to recover ethanol. The obtained extract is extracted with sulfuric acid. The extract is adjusted to pH9-10 by adding sodium carbonate, and extracted with chloroform. The extract is distilled to recover the chloroform to obtain total biomass. alkali, and then separate and form a salt to obtain this product. The total yield is 0.15%.
Purpose
Anticholinergics. Scopolamine is an alkaloid with the strongest pharmacological effect in scopolamine. It can be used to block parasympathetic nerves and can also be used as a central nervous system preparation. It acts like belladonna, but is stronger and shorter-lived. It can be used for anesthesia, analgesia, cough and asthma, and is effective for motion sickness. It can also be used to control stiffness and tremor in Parkinson’s disease.
Biochemical research.
The active ingredient of Huatu’s Mafei Powder is scopolamine. Use the goldenrod powder with 50℃Ethanol was percolated until the exudate was almost free of alkaloids. The leachate is distilled under reduced pressure to recover ethanol. The obtained extract is extracted with sulfuric acid. The extract is adjusted to pH9-10 by adding sodium carbonate, and extracted with chloroform. The extract is distilled to recover the chloroform to obtain total biomass. alkali, and then separate and form a salt to obtain this product. The total yield is 0.15%.
Purpose
Anticholinergics. Scopolamine is an alkaloid with the strongest pharmacological effect in scopolamine. It can be used to block parasympathetic nerves and can also be used as a central nervous system preparation. It acts like belladonna, but is stronger and shorter-lived. It can be used for anesthesia, analgesia, cough and asthma, and is effective for motion sickness. It can also be used to control stiffness and tremor in Parkinson’s disease.
Biochemical research.
