sulfaacetyl
Structural formula
| Business number | 03WL |
|---|---|
| Molecular formula | C8H10N2O3S |
| Molecular weight | 214.24 |
| label |
N-(4-aminobenzenesulfonyl)acetamide, acesulfonamide sodium salt, acesulfonamide, N-(4-Aminobenzenesulfonyl)acetamide |
Numbering system
CAS number:144-80-9
MDL number:MFCD00066501
EINECS number:205-640-6
RTECS number:AC8450000
BRN number:981718
PubChem number:24899803
Physical property data
1. Physical property data:
1. Character:White crystalline powder
-bidi-font-family: Tahoma”>2. Melting point (ºC): 182-184ºC
3. Solubility:Soluble in ethanol, slightly soluble in water or ether, almost insoluble in chloroform or benzene, soluble in dilute mineral acid or alkali hydroxide Solution.
Toxicological data
2. Toxicological data:
1, acute toxicity: rat intravenous LD50: 6600 mg/kg;
Mouse oral LD50: 16500 mg/kg;
Mouse abdominal cavity LD50: 606 mg/kg.
2. Reproductive toxicity: RatTDLo: 10 gm/kg
Ecological data
3. Ecological data:
Other harmful Effect: This substance may be harmful to the environment, and special attention should be paid to water bodies.
Molecular structure data
5. Molecular property data: 1. Molar refractive index:52.21 2. Molar volume (m3/mol):155.9 3. Isotonic specific volume (90.2K):424.7 4. Surface tension (dyne/cm):55.0 5. Polarizability(10-24cm3）：20.69
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond acceptors: 4
4. Number of rotatable chemical bonds: 2
5. Number of tautomers: 2
6. Topological molecule polar surface area 97.6
7. Number of heavy atoms: 14
8. Surface charge: 0
9. Complexity: 299
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
Stable under normal temperature and pressure. 2. Moore Volume (m3/mol ): 155.9
3. Isotonic specific volume (90.2K):424.7
4. Surface tension (dyne/cm):55.0
5. Polarizability(10-24cm3）：20.69
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond acceptors: 4
4. Number of rotatable chemical bonds: 2
5. Number of tautomers: 2
6. Topological molecule polar surface area 97.6
7. Number of heavy atoms: 14
8. Surface charge: 0
9. Complexity: 299
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
Stable under normal temperature and pressure.
Storage method
Save at 0-6ºC.
Synthesis method
Obtained by acidification of sodium sulfonamide acetate. Dissolve sodium sulfonamide acetate in water and use 5%Hydrochloric acid is adjusted to pH3.8-4 to precipitate sulfonamide acetyl. Filter, wash and dry to get the finished product.
Purpose
Medicine, used to treat conjunctivitis, trachoma and other eye infections.
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Storage method
Save at 0-6ºC.
Synthesis method
Obtained by acidification of sodium sulfonamide acetate. Dissolve sodium sulfonamide acetate in water and use 5%Hydrochloric acid is adjusted to pH3.8-4 to precipitate sulfonamide acetyl. Filter, wash and dry to get the finished product.
Purpose
Medicine, used to treat conjunctivitis, trachoma and other eye infections.
