2-fluoroethanol
Structural formula
| Business number | 04HZ |
|---|---|
| Molecular formula | C2H5OF |
| Molecular weight | 64.06 |
| label |
Aliphatic alcohols, ethers and their derivatives |
Numbering system
CAS number:371-62-0
MDL number:MFCD00002828
EINECS number:206-740-2
RTECS number:KL1575000
BRN number:1730857
PubChem number:24849864
Physical property data
1. Physical property data
Properties: Colorless liquid with alcohol smell
Density (g/ mL, 25/4℃): 1.1002
Pair density (20℃, 4℃): 1.1040
Melting point (ºC): – 26.4
Boiling point (ºC, normal pressure): 103.5
Refractive index at normal temperature (n20): 1.3640
Refractive index: 1.3647
Refractive index at room temperature (n25): 1.3632
Gas phase standard claimed heat (enthalpy) (kJ·mol-1): -419.7
Liquid phase standard claimed heat (enthalpy) (kJ·mol-1): -463.6
Vapor pressure (kPa, 25ºC): Not available
Saturated vapor pressure (kPa, 60ºC): Not available
Heat of combustion (KJ/mol): Not available
Critical temperature (ºC ): Not available
Critical pressure (KPa): Not available
Log value of oil-water (octanol/water) partition coefficient: Not available Use
Upper limit of explosion (%,V/V): Not available
Lower limit of explosion (%,V/V): Not available
Solubility: miscible with water and many organic solvents
Toxicological data
2. Toxicological data:
Acute toxicity: Not available.
Ecological data
3. Ecological data:
1. Other harmful effects: This substance may be harmful to the environment, and special attention should be paid to water bodies.
Molecular structure data
1. Molar refractive index: 13.01
2. Molar volume (cm3/mol): 64.5
3. Isotonic specific volume (90.2K ): 137.9
4. Surface tension (dyne/cm): 20.9
5. Polarizability (10-24cm3): 5.15
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond acceptors: 2
4. Number of rotatable chemical bonds: 1
5. Number of tautomers: none
6. Topological molecule polar surface area 20.2
7. Number of heavy atoms: 4
8. Surface charge: 0
9. Complexity: 10
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Sex� and stability
1. Properties: Colorless liquid with an alcoholic smell. It is stable in nature and does not decompose during distillation. Miscible with water and many organic solvents. The chemical properties are similar to those of general alcohols, and the corresponding aldehydes and acids can be obtained after oxidation. Reacts with alkali metals or alkaline earth metals to form alkoxides, thereby producing ethers
2. It is highly toxic, mice were injected intraperitoneally with LD5060mg /kg. Production equipment should be sealed and operated under negative pressure. The workshop should have good ventilation. Operators should wear protective equipment.
Storage method
The product should be packed in brown glass bottles and packed in wooden boxes.
Synthesis method
Add 96.6g (1.2mol) of 2-chloroethanol dropwise into a mixture of 94ml of ethylene glycol and 105g (1.8mol) of anhydrous potassium fluoride, and react at 180°C for 2 hours to obtain 32.34g of 2-fluoroethanol. The yield is 42.1%.
Purpose
Intermediates of the antibacterial drug fleroxacin. 2-Fluoroethanol and its derivatives are used to poison rodents, and its derivatives can be used as herbicides and poison some plant pests.