Acetamide Acetamide
Structural formula
| Business number | 01BD |
|---|---|
| Molecular formula | C2H5NO |
| Molecular weight | 59.07 |
| label |
Acetamide, ammonium acetate, Acetic acid amide, Ethanamide, Acetimidic acid, Solubilizers, Stabilizer for plasticizers, antacids, Wetting agents for the paper industry, Nitrogen-containing compound solvent |
Numbering system
CAS number:60-35-5
MDL number:MFCD00008023
EINECS number:200-473-5
RTECS number:AB4025000
BRN number:1071207
PubChem number:24849056
Physical property data
1. Properties: colorless hexagonal crystal. The pure product is odorless, but usually has a rat odor.
2. Boiling point (ºC, 101.3kPa): 221.15
3. Melting point (ºC): 81
4. Relative density (g/mL, 91.1 /4ºC): 0.9892
5. Relative density (g/mL,111.8/4ºC): 0.9711
6. Relative density (d204) : 1.159
7. Refractive index (80ºC): 1.4270
8. Refractive index (110ºC): 1.4158
9. Refractive index (130ºC): 1.4079
10. Viscosity (mPa·s, 91.1ºC): 2.182
11. Viscosity (mPa·s, 111.8ºC): 1.46
12. Viscosity (mPa·s, 131.7ºC): 1.056
13. Flash point (ºC, closed): >104
14. Fire point (ºC): 445
15. Heat of evaporation (KJ/mol, b.p.): 56.1
16. Heat of fusion (KJ/mol, 80ºC): 15.717
17. Heat of formation (KJ/mol): -320.7
18. Heat of combustion (KJ/mol, 25ºC, liquid): 1199.5
19. Specific heat capacity (KJ/(kg·K) , 80~150ºC, constant pressure): 2.81
20. Conductivity (S/m, 83.2ºC): 8.8×10-7
21 . Conductivity (S/m, 100ºC): 4.3×10-7
22. Freezing point (ºC): 80
23. Solubility: Soluble in liquid ammonia, aliphatic amines, water, alcohol, pyridine, chloroform, glycerin, hot benzene, methyl ethyl ketone, butanol, benzyl alcohol, cyclohexanone, isoamyl alcohol, etc., slightly soluble in benzene, insoluble in ether. Can dissolve most inorganic salts well.
Toxicological data
Low toxicity, oral LD50 in rats is0929/201009290927294698.gif” jquery1285723246906=”434″ alt=”” />
The generated ammonium acetate is heated and distilled (distilled above 190℃ and simultaneously Collect the product).
3. In the 1500L reaction jacketed tank,
Put 300kg of ethyl acetate and 500kg of ammonia water, stir at 25~27°C for 2~3h, leave it for 20h, and take the reaction solution. If stratification occurs, continue the reaction until there is no stratification.
After the reaction is completed, it is evaporated to 1/2 of the original volume under normal pressure, filtered, and the clear filtrate is concentrated under reduced pressure until slightly mixed, and cooled Crystallize, centrifuge and spin dry. If the CH3COO– content is unqualified, soak it in ethanol for 0.5h, centrifuge and dry, and the finished product is ready.
Purpose
1. Molten acetamide is an excellent solvent for a variety of organic and inorganic substances. It can be used as a solubilizer when some substances with low water solubility are dissolved in water, such as solvents and solubilizers for dyes in the fiber industry. It is also widely used as a stabilizer for plasticizers, an antacid in the cosmetics industry, a wetting agent in the paper industry, and as a solvent in the synthesis of antibiotics such as chloramphenicol.
2.Used as analytical reagents, solvents, stabilizers, and plasticizers. It can also be used in organic synthesis, pharmaceutical industry, and dye preparation.
3. Also used to make hygroscopic agents, lubricants, etc.