Corticosterone Corticosterone
Structural formula
| Business number | 013A |
|---|---|
| Molecular formula | C21H30O4 |
| Molecular weight | 346.46 |
| label |
corticosterone, adrenaline corticosterone, adrenaline, 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance |
Numbering system
CAS number:50-22-6
MDL number:MFCD00037715
EINECS number:200-019-6
RTECS number:GM7650000
BRN number:2339601
PubChem number:24278302
Physical property data
1. Properties: White crystalline powder, odorless, initially tasteless, then has a persistent bitter taste
2. Density (g/mL, 25/4℃): Undetermined
3. Relative vapor density (g/mL, air=1): Undetermined
4. Melting point (ºC): 179-183 °C (lit.)
5. Boiling point (ºC, normal pressure): Undetermined
6. Boiling point (ºC, 5.2 kPa): Undetermined
7. Refractive index: Undetermined
8. Flash point (ºC): Undetermined
9. Specific rotation (º): Undetermined
10. Autoignition point or ignition temperature (ºC): Undetermined Determined
11. Vapor pressure (kPa, 25 ºC): Undetermined
12. Saturated vapor pressure (kPa, 60 ºC): Undetermined
13 . Heat of combustion (KJ/mol): Undetermined
14. Critical temperature (ºC): Undetermined
15. Critical pressure (KPa): Undetermined
16. The logarithmic value of the oil-water (octanol/water) partition coefficient: Undetermined
17. The upper limit of explosion (%, V/V): Undetermined
18. Explosion Lower limit (%, V/V): Undetermined
19. Solubility: Easily soluble in methanol, ethanol, chloroform, slightly soluble in ether, benzene, acetone, not soluble in water, soluble in concentrated sulfuric acid It turns into an orange-red solution with strong green fluorescence
Toxicological data
None
Ecological data
None
Molecular structure data
1. Molar refractive index: 94.03
2. Molar volume (cm3/mol): 284.0
3. Isotonic specific volume (90.2K ): 762.2
4. Surface tension (dyne/cm): 51.8
5. Polarizability (10-24cm3)���37.27
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond acceptors: 4
4. Number of rotatable chemical bonds: 2
5. Number of tautomers: 20
6. Topological molecule polar surface area 74.6
7. Number of heavy atoms: 25
8. Surface charge: 0
9. Complexity: 638
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 7
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
This product should be sealed and stored in a dry place away from light.
Synthesis method
It can be isolated from adrenal gland extract, or made from bile acid, yam saponin, etc.
Purpose
An adrenocortical hormone. It is used as an alternative treatment for adrenal insufficiency, but has serious side effects.