Griseofulvin Griseofulvin
Structural formula
| Business number | 03JW |
|---|---|
| Molecular formula | C17H17ClO6 |
| Molecular weight | 352.77 |
| label |
7-Chloro-2′,4,6-trimethoxy-6′β-methyl-spiral-{benzofuran-2(3H)-1′-[2]cyclohexene}-3,4′- dione, Fulcin, Fulvina, Fulvistatin, Grisactin, Grizeofulvin, Fungicide |
Numbering system
CAS number:126-07-8
MDL number:MFCD00082343
EINECS number:204-767-4
RTECS number:WG9800000
BRN number:95226
PubChem number:24850369
Physical property data
1. Properties: white or off-white powder, odorless or almost odorless, slightly bitter taste
2. Melting point: 218-224℃
3. Specific optical rotation: +370°
4. Solubility: easily soluble in tetrachloroethane, soluble in acetone or chloroform, slightly soluble in methanol or ethanol, very slightly soluble in water
Toxicological data
None
Ecological data
None
Molecular structure data
5. Molecular property data:
1. Molar refractive index: 80.66
2. Molar volume (m3/mol):238.3
3. isotonic specific volume (90.2K):648.9
4. Surface Tension (dyne/cm):54.9
5. Polarizability（10-24cm3):31.97
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 0
3. Number of hydrogen bond acceptors: 6
4. Number of rotatable chemical bonds: 3
5. Number of tautomers: 2
6. Topological molecule polar surface area 71.1
7. Number of heavy atoms: 24
8. Surface charge: 0
9. Complexity: 575
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 2
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
Basic properties: This product is an antibiotic that has a strong effect on killing mold on the body surface. It is stable to heat and does not decompose when exposed to heat.
Storage method
Storage: Store at room temperature.
Synthesis method
Brief description of the production method: Griseofulvin is an antibiotic extracted from the culture and fermentation broth of Penicilli-um griseofulvum.
Purpose
Usage: This product has inhibitory effects on various dermatophytes, including Epidermophyton, Dermatophyton and Microsporum. Ineffective against tinea versicolor, albicans and bacteria. This product has a bacteriostatic effect and is effective against vigorously growing fungi. This product is used for tinea capitis, onychomycosis, tinea shingles, tinea pedis and tinea corporis caused by sensitive fungi.