L-Leucine L-Leucine
Structural formula
| Business number | 01C4 |
|---|---|
| Molecular formula | C6H13NO2 |
| Molecular weight | 131.17 |
| label |
L-2-amino-4-methylpentanoic acid, L-Leucine, L-α-aminoisobutylacetic acid, L-α-Aminoisocaproic acid, (S)-2-Isohexanine, (S)-2-Amino-4-methylpentanoic acid, L-Leucine, (s)-(+)-Leucine, amino acid drugs, intermediates, Biochemical reagents |
Numbering system
CAS number:61-90-5
MDL number:MFCD00002617
EINECS number:200-522-0
RTECS number:OH2850000
BRN number:1721722
PubChem number:24896510
Physical property data
1. Properties: White shiny hexahedral crystals or white crystalline powder
2. Density (g/mL, 25/4℃): 1.293
3. Relative steam Density (g/mL, air=1): Uncertain
4. Melting point (ºC): 293(lit.)
5. Boiling point (ºC, normal pressure): Unknown Confirm
6. Boiling point (ºC, 5.2kPa): Uncertain
7. Refractive index: Uncertain
8. Flash point (ºC): 145 -148
9. Specific rotation (º): 15.4 º (c=4, 6N HCl)
10. Autoignition point or ignition temperature (ºC): Uncertain
11. Vapor pressure (kPa, 25ºC): Uncertain
12. Saturated vapor pressure (kPa, 60ºC): Uncertain
13. Heat of combustion ( KJ/mol): Uncertain
14. Critical temperature (ºC): Uncertain
15. Critical pressure (KPa): Uncertain
16. Log value of oil-water (octanol/water) partition coefficient: Uncertain
17. Explosion upper limit (%, V/V): Uncertain
18. Explosion lower limit (%, V/V): Uncertain
19. Solubility: In the presence of hydrocarbons, it has stable performance in inorganic acid aqueous solutions. Each g is dissolved in about 40ml of water and about 100ml of acetic acid. Slightly soluble in ethanol (0.07%), soluble in dilute hydrochloric acid and alkaline hydroxide and carbonate solutions. Insoluble in ether
Toxicological data
Acute toxicity: rat intraperitoneal LD50: 5379 mg/kg; rabbit subcutaneous injection LDLo: 2620 mg/kg; mutagenicity: human lymphocyte Sister chromatid exchangeTEST SYSTEM: 10ml/L; breeding: rat oral TDLo: 138 gm/kgSEX /DURATION: female 5-15 days(s) after conception;
Rat intraperitoneal TDLo: 90 mg/kgSEX/DURATION: female 1-6 day(s) after conception
Ecological data
None yet
Molecular structure data
1. Molar refractive index: 34.86
2. Molar volume (cm3/mol): 126.6
3. Isotonic specific volume (90.2K): 316.4
4. Surface tension (dyne/cm): 39.0
5. Polarizability (10-24cm3): 13.82
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond acceptors: 3
4. Number of rotatable chemical bonds: 3
5. Number of tautomers: none
6. Topological molecule polar surface area 63.3
7. Number of heavy atoms: 9
8. Surface charge: 0
9. Complexity: 101
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 1
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
1. Exists in flue-cured tobacco leaves, burley tobacco leaves, and smoke.
2. There are three isomers: left-handed body, right-handed body and racemate.
Storage method
This product should be sealed, dry and protected from light.
Synthesis method
1. Protein (casein, keratin, etc.) is hydrolyzed with hydrochloric acid or dilute sulfuric acid. The hydrolyzate is neutralized with alkali to precipitate a mixture of leucine, L-isoleucine and L-methionine. Use the copper salt method Refined, and used β-naphthalenesulfonic acid to precipitate L-leucine to obtain pure product.
2.Extraction method
3.Fermentation method
4. Enzyme method
5. Tobacco: BU, 22; FC, 21. It is obtained by hydrolyzing and refining proteins such as gluten and corn protein. It can also be synthesized chemically.
Purpose
1. It is an essential amino acid. Adult men require 2.2g/d. It is necessary for normal growth of infants and maintenance of normal nitrogen balance for adults. This product is used as a nutritional supplement to prepare amino acid infusions and comprehensive amino acid preparations, hypoglycemic agents, and plant growth promoters. According to my country’s GB 2760-86 regulations, this product can be used as a spice.
2.As amino acid infusion and comprehensive amino acid preparation. For the diagnosis and treatment of idiopathic hyperglycemia in young children. It is also suitable for glucose metabolism disorders, liver disease with
reduced bile secretion, anemia, poisoning, muscular atrophy, sequelae of poliomyelitis, neuritis and mental illness.