Tolbutamide Tolbutamide
Structural formula
| Business number | 01DJ |
|---|---|
| Molecular formula | C12H18N2O3S |
| Molecular weight | 270.35 |
| label |
1-n-Butyl-3-(4-methylsulfonyl)urea, 1-Butyl-3-(4-methylphenylsulfonyl)urea |
Numbering system
CAS number:64-77-7
MDL number:MFCD00027169
EINECS number:200-594-3
RTECS number:YS4550000
BRN number:1984428
PubChem number:24277742
Physical property data
1. Character:White crystalline powder. Odorless and tasteless
2. Density (g/mL,25/4℃): Unsure
3. Relative vapor density (g/mL,AIR=1): Unsure
4. Melting point (ºC):128 -130
5. Boiling point (ºC,Normal pressure): Uncertain
6. Boiling point (ºC, 5.2kPa): Unsure
7. Refractive index:Not sure
8. Flash point (ºC): Unsure
9. Specific optical rotation (º): Unsure
10. Autoignition point or ignition temperature (ºC): Unsure
11. Vapor pressure (kPa,25ºC): Unsure
12. <SPAN style="FONT-SIZE: 9pt; FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-fa): 583.5
4. Surface Tension (dyne/cm):42.7
5. Polarizability（10-24cm3): 28.05
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond acceptors: 3
4. Number of rotatable chemical bonds: 5
5. Number of tautomers: 3
6. Topological molecule polar surface area 83.6
7. Number of heavy atoms: 18
8. Surface charge: 0
9. Complexity: 354
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None yet
Storage method
This product should be sealed in 0℃Save the following in a dry place and away from light.
Synthesis method
Prepared from the condensation of butyl isocyanate and p-toluenesulfonamide, or from the condensation of n-butylamine hydrochloride and toluenesulfonylurea become.
Purpose
A hypoglycemic drug, suitable for adult patients with stable mild to moderate diabetes.
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Purpose
A hypoglycemic drug, suitable for adult patients with stable mild to moderate diabetes.