Uridine Uridine
Structural formula
| Business number | 01A1 |
|---|---|
| Molecular formula | C9H12N2O6 |
| Molecular weight | 244.2 |
| label |
uridine, Uracil nucleoside; dihydropyrimidine nucleoside, 1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside |
Numbering system
CAS number:58-96-8
MDL number:MFCD00006526
EINECS number:200-407-5
RTECS number:YR1450000
BRN number:754902
PubChem number:24900434
Physical property data
1. Properties: White needle-like crystals or powder. Odorless. The taste is slightly sweet and slightly pungent
2. Density (g/mL, 25/4℃): Undetermined
3. Relative steam density (g/mL, air=1) : Undetermined
4. Melting point (ºC): 165
5. Boiling point (ºC, normal pressure): Undetermined
6. Boiling point (ºC, 5.2kPa): Not determined
7. Refractive index: Not determined
8. Flash point (ºC): Not determined
9. Specific rotation ( º): 8.4° (c=2, water)
10. Autoignition point or ignition temperature (ºC): Undetermined
11. Vapor pressure (kPa, 25ºC): Undetermined
12. Saturated vapor pressure (kPa, 60ºC): Undetermined
13. Heat of combustion (KJ/mol): Undetermined
14. Critical temperature (ºC): Undetermined
15. Critical pressure (KPa): Undetermined
16. Log value of oil-water (octanol/water) partition coefficient: Undetermined
17. Explosion upper limit (%, V/V): Undetermined
18. Explosion lower limit (%, V/V): Undetermined
19. Solubility: Slightly soluble in dilute alcohol, insoluble in absolute ethanol
Toxicological data
1. Acute toxicity: mouse abdominal cavity LD50: 4335mg/kg
2. Mutagenicity: micronucleus test: mouse abdominal cavity: 740mg/kg; DNA damageTEST system: mammal – species not lymphocytes: 100nmol/L
Ecological data
None yet
Molecular structure data
1. Molar refractive index: 52.73
2. Molar volume (cm3/mol): 145.7
3. Isotonic specific volume (90.2K): 447.1
4. Surface tension (dyne/cm): 88.5
5. Polarizability (10-24cm3): 20.90
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): -2
2. Number of hydrogen bond donors: 4
3. Number of hydrogen bond acceptors: 6
4. Number of rotatable chemical bonds: 2
5. Number of tautomers: 3
6. Topological molecular polar surface area (TPSA): 119
7, Number of heavy atoms: 17
8, Surface charge: 0
9, Complexity: 371
10. Number of isotope atoms: 0
11. Number of determined atomic stereocenters: 4
12. Number of uncertain atomic stereocenters: 0
13. The number of determined stereocenters of chemical bonds: 0
14. The number of uncertain stereocenters of chemical bonds: 0
15. The number of covalent bond units: 1
Properties and stability
Uridine is a related component of nucleic acid in animal cells and can increase the body’s antibody levels. Animal experiments show that the combination of uridine and inosine can promote myocardial cell metabolism, accelerate protein and nucleic acid biosynthesis and energy production, and can promote and improve brain cell metabolism.
Storage method
This product should be sealed and stored away from light.
Synthesis method
1. It can be prepared with 2,4-dichloro(trimethylsiloxy)pyrimidine.
Purpose
Uridine is a drug, such as anti-giant red blood cell anemia, treatment of liver, cerebrovascular, cardiovascular and other diseases. It is also a manufacturer of fluorouracil (S-FC), deoxynucleoside, iodoside (IDUR), bromoside (BUDR) ), fluoroside (FUDR) and other drugs are the main raw materials.